For decades, computational biology has operated under a reductionist compromise. To fit complex biological systems into the limited memory of a single GPU,...For decades, computational biology has operated under a reductionist compromise. To fit complex biological systems into the limited memory of a single GPU, researchers have had to deconstruct them into isolated fragments—single proteins or small domains. This created a context gap, where larger proteins or complexes could not be folded zero-shot due to GPU hardware memory constraints. Now…

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